Dichotomies properties on computational complexity of S-packing coloring problems

This work establishes the complexity class of several instances of the S-packing coloring problem: for a graph G, a positive integer k and a non decreasing list of integers S = (s\_1 , ..., s\_k ), G is S-colorable, if its vertices can be partitioned into sets S\_i , i = 1,... , k, where each S\_i being a s\_i -packing (a set of vertices at pairwise distance greater than s\_i). For a list of three integers, a dichotomy between NP-complete problems and polynomial time solvable problems is determined for subcubic graphs. Moreover, for an unfixed size of list, the complexity of the S-packing coloring problem is determined for several instances of the problem. These properties are used in order to prove a dichotomy between NP-complete problems and polynomial time solvable problems for lists of at most four integers

S-Packing Colorings of Cubic Graphs

Given a non-decreasing sequence $S=(s\_1,s\_2, \ldots, s\_k)$ of positive integers, an {\em $S$-packing coloring} of a graph $G$ is a mapping $c$ from $V(G)$ to $\{s\_1,s\_2, \ldots, s\_k\}$ such that any two vertices with color $s\_i$ are at mutual distance greater than $s\_i$, $1\le i\le k$. This paper studies $S$-packing colorings of (sub)cubic graphs. We prove that subcubic graphs are $(1,2,2,2,2,2,2)$-packing colorable and $(1,1,2,2,3)$-packing colorable. For subdivisions of subcubic graphs we derive sharper bounds, and we provide an example of a cubic graph of order $38$ which is not $(1,2,\ldots,12)$-packing colorable

A characterization of b-chromatic and partial Grundy numbers by induced subgraphs

Gy{\'a}rf{\'a}s et al. and Zaker have proven that the Grundy number of a graph $G$ satisfies $\Gamma(G)\ge t$ if and only if $G$ contains an induced subgraph called a $t$-atom.The family of $t$-atoms has bounded order and contains a finite number of graphs.In this article, we introduce equivalents of $t$-atoms for b-coloring and partial Grundy coloring.This concept is used to prove that determining if $\varphi(G)\ge t$ and $\partial\Gamma(G)\ge t$ (under conditions for the b-coloring), for a graph $G$, is in XP with parameter $t$.We illustrate the utility of the concept of $t$-atoms by giving results on b-critical vertices and edges, on b-perfect graphs and on graphs of girth at least $7$

Subdivision into i-packings and S-packing chromatic number of some lattices

An $i$-packing in a graph $G$ is a set of vertices at pairwise distance greater than $i$. For a nondecreasing sequence of integers $S=(s\_{1},s\_{2},\ldots)$, the $S$-packing chromatic number of a graph $G$ is the least integer $k$ such that there exists a coloring of $G$ into $k$ colors where each set of vertices colored $i$, $i=1,\ldots, k$, is an $s\_i$-packing. This paper describes various subdivisions of an $i$-packing into $j$-packings (j\textgreater{}i) for the hexagonal, square and triangular lattices. These results allow us to bound the $S$-packing chromatic number for these graphs, with more precise bounds and exact values for sequences $S=(s\_{i}, i\in\mathbb{N}^{*})$, $s\_{i}=d+ \lfloor (i-1)/n \rfloor$

Partitionnement, recouvrement et colorabilité dans les graphes

Our research are about graph coloring with distance constraints (packing coloring) or neighborhood constraints (Grundy coloring). Let S={si| i in N*} be a non decreasing sequence of integers. An S-packing coloring is a proper coloring such that every set of color i is an si-packing (a set of vertices at pairwise distance greater than si). A graph G is (s1,... ,sk)-colorable if there exists a packing coloring of G with colors 1,... ,k. A Grundy coloring is a proper vertex coloring such that for every vertex of color i, u is adjacent to a vertex of color j, for each ji. These results allow us to determine S-packing coloring of these lattices for several sequences of integers. We examine a class of graph that has never been studied for S-packing coloring: the subcubic graphs. We determine that every subcubic graph is (1,2,2,2,2,2,2)-colorable and (1,1,2,2,3)-colorable. Few results are proven about some subclasses. Finally, we study the Grundy number of regular graphs. We determine a characterization of the cubic graphs with Grundy number 4. Moreover, we prove that every r-regular graph without induced square has Grundy number r+1, for ri. Ces résultats nous permettent de déterminer des S-colorations de packings de ces grilles pour plusieurs séries d’entiers. Nous examinons une classe de graphe jamais étudiée en ce qui concerne la S -coloration de packing: les graphes subcubiques. Nous déterminons que tous les graphes subcubiques sont (1,2,2,2,2,2,2)-colorables et (1,1,2,2,3)-colorables. Un certain nombre de résultats sont prouvés pour certaines sous-classes des graphes subcubiques. Pour finir, nous nous intéressons au nombre de Grundy des graphes réguliers. Nous déterminons une caractérisation des graphes cubiques avec un nombre de Grundy de 4. De plus, nous prouvons que tous les graphes r-réguliers sans carré induit ont pour nombre de Grundy de r+1, pour r<5

Completely Independent Spanning Trees in Some Regular Graphs

Let $k\ge 2$ be an integer and $T_1,\ldots, T_k$ be spanning trees of a graph $G$. If for any pair of vertices $(u,v)$ of $V(G)$, the paths from $u$ to $v$ in each $T_i$, $1\le i\le k$, do not contain common edges and common vertices, except the vertices $u$ and $v$, then $T_1,\ldots, T_k$ are completely independent spanning trees in $G$. For $2k$-regular graphs which are $2k$-connected, such as the Cartesian product of a complete graph of order $2k-1$ and a cycle and some Cartesian products of three cycles (for $k=3$), the maximum number of completely independent spanning trees contained in these graphs is determined and it turns out that this maximum is not always $k$

Functional abdominal pain disorders and patient- and parent- reported outcomes in children with inflammatory bowel disease in remission

BACKGROUND: Chronic abdominal pain occurs frequently in pediatric patients with inflammatory bowel disease (IBD) in remission. AIMS: To assess the prevalence and factors associated with Functional Abdominal Pain Disorders among IBD children in remission (IBD-FAPD). METHODS: Patients with IBD for > 1 year, in clinical remission for ≥ 3 months were recruited from a National IBD network. IBD-FAPDs were assessed using the Rome III questionnaire criteria. Patient- or parent- reported outcomes were assessed. RESULTS: Among 102 included patients, 57 (56%) were boys, mean age (DS) was 15.0 (± 2.0) years and 75 (74%) had Crohn's disease. Twenty-two patients (22%) had at least one Functional Gastrointestinal Disorder among which 17 had at least one IBD-FAPD. Past severity of disease or treatments received and level of remission were not significantly associated with IBD-FAPD. Patients with IBD-FAPD reported more fatigue (peds-FACIT-F: 35.9 ± 9.8 vs. 43.0 ± 6.9, p = 0.01) and a lower HR-QoL (IMPACT III: 76.5 ± 9.6 vs. 81.6 ± 9.2, p = 0.04) than patients without FAPD, and their parents had higher levels of State and Trait anxiety than the other parents. CONCLUSIONS: Prevalence of IBD-FAPD was 17%. IBD-FAPD was not associated with past severity of disease, but with fatigue and lower HR-QoL

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Partitionability, coverability and colorability in graphs

Nos recherches traitent de coloration de graphes avec des contraintes de distance (coloration de packing) ou des contraintes sur le voisinage (coloration de Grundy). Soit S={si| i in N*} une série croissante d’entiers. Une S -coloration de packing est une coloration propre de sommets telle que tout ensemble coloré i est un si-packing (un ensemble où tous les sommets sont à distance mutuelle supérieure à si). Un graphe G est (s1,... ,sk)-colorable si il existe une S -coloration de packing de G avec les couleurs 1, ...,,k. Une coloration de Grundy est une coloration propre de sommets telle que pour tout sommet u coloré i, u est adjacent à un sommet coloré j, pour chaque ji. Ces résultats nous permettent de déterminer des S-colorations de packings de ces grilles pour plusieurs séries d’entiers. Nous examinons une classe de graphe jamais étudiée en ce qui concerne la S -coloration de packing: les graphes subcubiques. Nous déterminons que tous les graphes subcubiques sont (1,2,2,2,2,2,2)-colorables et (1,1,2,2,3)-colorables. Un certain nombre de résultats sont prouvés pour certaines sous-classes des graphes subcubiques. Pour finir, nous nous intéressons au nombre de Grundy des graphes réguliers. Nous déterminons une caractérisation des graphes cubiques avec un nombre de Grundy de 4. De plus, nous prouvons que tous les graphes r-réguliers sans carré induit ont pour nombre de Grundy de r+1, pour ri. These results allow us to determine S-packing coloring of these lattices for several sequences of integers. We examine a class of graph that has never been studied for S-packing coloring: the subcubic graphs. We determine that every subcubic graph is (1,2,2,2,2,2,2)-colorable and (1,1,2,2,3)-colorable. Few results are proven about some subclasses. Finally, we study the Grundy number of regular graphs. We determine a characterization of the cubic graphs with Grundy number 4. Moreover, we prove that every r-regular graph without induced square has Grundy number r+1, for r<5